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KMID : 0381019900230060451
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Korean Journal of Nutrition
1990 Volume.23 No. 6 p.451 ~ p.457
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Effect of Estrone Treatment of Proteinuria in Maturing Lean and Obese Male SHR/Mcc-cp Rats
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Park Son-Hee
McCune, Sylvia A.
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Abstract
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Lean and obese male spontaneously hyperten5ive(SHB/Mcc-cp) rats were fed a ground rat chow diet with or without 0.001% estrone added from 6 to lSweeks o f age. Urine samples were collected weekly wirh 24hour fasting. Both control lean and obese rats showed significantly higher urinary prorein than their estrone treated counterparts. Treatment with
0.001% estrone diet was found to reduce the proteinuria In the maturing lean and obese SHR/Mcc-cp fats. Peaks in urinary prorein level were noted at l6weeks o f age in both lean and obese control rats. Both control and estrone treated lean rars showed higher proteinuria than the obese rats. Therefore, obesity docs nor appear to be a contributing factor to the proteinuria in young male SHR/Mcc-cp rats.
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KEYWORD
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proteinuria, estrone, obesity
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